ADRA2B anticorps

N° du produit ABIN1944814

Cet anticorps Lapin Polyclonal détecte spécifiquement ADRA2B dans WB et IF. Il présente une réactivité envers Humain et a été mentionné dans 4+ publications.

Aperçu rapide pour ADRA2B anticorps (ABIN1944814)

Antigène: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRA2B est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-ADRA2B anticorps

Isotype: IgG1

Information d'application

Indications d'application: IF: 1:100. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C,-20 °C

Références pour anticorps anti-ADRA2B (ABIN1944814)

Cayla, Heinonen, Viikari, Schaak, Snapir, Bouloumié, Karvonen, Pesonen, Scheinin, Paris: "Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene." dans: Biochemical pharmacology, Vol. 67, Issue 3, pp. 469-78, (2004) (PubMed).

Small, Brown, Forbes, Liggett: "Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization." dans: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4917-22, (2001) (PubMed).

Lomasney, Lorenz, Allen, King, Regan, Yang-Feng, Caron, Lefkowitz: "Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 13, pp. 5094-8, (1990) (PubMed).

Weinshank, Zgombick, Macchi, Adham, Lichtblau, Branchek, Hartig: "Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor." dans: Molecular pharmacology, Vol. 38, Issue 5, pp. 681-8, (1990) (PubMed).

Détails sur ADRA2B

Antigène: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Autre désignation: Adrenergic Receptor alpha-2B

Sujet: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Poids moléculaire: 49954 Da

ID gène: 151

UniProt: P18089

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process