Endoglin anticorps (PE)

N° du produit ABIN1981859

Détail du produit anti-Endoglin anticorps (PE)

Antigène: Endoglin (ENG)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Endoglin est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: The rat monoclonal antibody MJ7/18 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow.

Réactivité croisée (Details): Mouse

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Inflamed mouse skin

Clone: MJ7-18

Isotype: IgG2a kappa

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-5 μg/mL.

Commentaires:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-Endoglin (PE) (ABIN1981859)

Dassler, Roohi, Lohrke, Ide, Remmele, Hütter, Pietsch, Pison, Schütz: "Current limitations of molecular magnetic resonance imaging for tumors as evaluated with high-relaxivity CD105-specific iron oxide nanoparticles." dans: Investigative radiology, Vol. 47, Issue 7, pp. 383-91, (2012) (PubMed).

Rosu-Myles, She, Fair, Muradia, Mehic, Menendez, Prasad, Cyr: "Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells." dans: PLoS ONE, Vol. 7, Issue 6, pp. e38954, (2012) (PubMed).

Fonsatti, Nicolay, Altomonte, Covre, Maio: "Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours." dans: Cardiovascular research, Vol. 86, Issue 1, pp. 12-9, (2010) (PubMed).

Warrington, Hillarby, Li, Letarte, Kumar: "Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells." dans: Anticancer research, Vol. 25, Issue 3B, pp. 1851-64, (2005) (PubMed).

Herouet, Cottin, LeClaire, Enk, Rousset: "Contact sensitizers specifically increase MHC class II expression on murine immature dendritic cells." dans: In vitro & molecular toxicology, Vol. 13, Issue 2, pp. 113-23, (2001) (PubMed).

Détails sur Endoglin

Antigène: Endoglin (ENG)

Autre désignation: CD105 (ENG Produits)

Synonymes: anticorps ENG, anticorps MGC137842, anticorps DKFZp469D0419, anticorps END, anticorps HHT1, anticorps ORW1, anticorps AI528660, anticorps AI662476, anticorps CD105, anticorps S-endoglin, anticorps endoglin, anticorps ENG, anticorps Eng

Sujet: Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG

ID gène: 13805

UniProt: Q63961