Endoglin anticorps
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- Antigène Voir toutes Endoglin (ENG) Anticorps
- Endoglin (ENG)
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Reactivité
- Souris
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Hôte
- Rat
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Endoglin est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- The rat monoclonal antibody MJ7/18 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow.
- Réactivité croisée (Details)
- Mouse
- Purification
- Purified by protein-G affinity chromatography.
- Pureté
- > 95 % (by SDS-PAGE)
- Immunogène
- Inflamed mouse skin
- Clone
- MJ7-18
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product ENG Anticorps primaire
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- Indications d'application
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Do not freeze. Do not use after expiration date stamped on vial label.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Do not freeze.
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Current limitations of molecular magnetic resonance imaging for tumors as evaluated with high-relaxivity CD105-specific iron oxide nanoparticles." dans: Investigative radiology, Vol. 47, Issue 7, pp. 383-91, (2012) (PubMed).
: "Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells." dans: PLoS ONE, Vol. 7, Issue 6, pp. e38954, (2012) (PubMed).
: "Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours." dans: Cardiovascular research, Vol. 86, Issue 1, pp. 12-9, (2010) (PubMed).
: "Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells." dans: Anticancer research, Vol. 25, Issue 3B, pp. 1851-64, (2005) (PubMed).
: "Contact sensitizers specifically increase MHC class II expression on murine immature dendritic cells." dans: In vitro & molecular toxicology, Vol. 13, Issue 2, pp. 113-23, (2001) (PubMed).
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Current limitations of molecular magnetic resonance imaging for tumors as evaluated with high-relaxivity CD105-specific iron oxide nanoparticles." dans: Investigative radiology, Vol. 47, Issue 7, pp. 383-91, (2012) (PubMed).
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- Antigène
- Endoglin (ENG)
- Autre désignation
- CD105 (ENG Produits)
- Synonymes
- anticorps ENG, anticorps MGC137842, anticorps DKFZp469D0419, anticorps END, anticorps HHT1, anticorps ORW1, anticorps AI528660, anticorps AI662476, anticorps CD105, anticorps S-endoglin, anticorps endoglin, anticorps ENG, anticorps Eng
- Sujet
- Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG
- ID gène
- 13805
- UniProt
- Q63961
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