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Fc gamma RII (CD32) anticorps

CD32 Reactivité: Humain FACS, CyTOF Hôte: Souris Monoclonal 3D3 unconjugated
N° du produit ABIN1981874
  • Antigène Voir toutes Fc gamma RII (CD32) Anticorps
    Fc gamma RII (CD32)
    Reactivité
    • 127
    • 10
    • 8
    • 7
    • 6
    • 5
    • 5
    • 3
    • 1
    • 1
    Humain
    Hôte
    • 71
    • 68
    Souris
    Clonalité
    • 74
    • 62
    • 3
    Monoclonal
    Conjugué
    • 46
    • 13
    • 11
    • 10
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Inconjugué
    Application
    • 77
    • 59
    • 22
    • 22
    • 12
    • 12
    • 10
    • 10
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)
    Specificité
    The mouse monoclonal antibody 3D3 recognizes an extracellular epitope of CD32, a 40 kDa polymorphic transmembrane glycoprotein serving as the low affinity receptor for aggregated IgG. This antibody recognizes CD32 isoforms on B cells of all donors, but on platelets, monocytes, and granulocytes of only some donors (131R variant, but not 131H variant).
    Réactivité croisée (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    purified glycosylated recombinant human FcgammaRIIa2
    Clone
    3D3
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD32 Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 2-6 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze. Do not use after expiration date stamped on vial label.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Os, Bürgler, Ribes, Funderud, Wang, Thompson, Tjønnfjord, Bogen, Munthe: "Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells." dans: Cell reports, Vol. 4, Issue 3, pp. 566-77, (2013) (PubMed).

    Dutertre, Bonnin-Gélizé, Pulford, Bourel, Fridman, Teillaud: "A novel subset of NK cells expressing high levels of inhibitory FcgammaRIIB modulating antibody-dependent function." dans: Journal of leukocyte biology, Vol. 84, Issue 6, pp. 1511-20, (2008) (PubMed).

    Boruchov, Heller, Veri, Bonvini, Ravetch, Young: "Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions." dans: The Journal of clinical investigation, Vol. 115, Issue 10, pp. 2914-23, (2005) (PubMed).

    Vely, Gruel, Moncuit, Cochet, Rouard, Dare, Galon, Sautes, Fridman, Teillaud: "A new set of monoclonal antibodies against human Fc gamma RII (CD32) and Fc gamma RIII (CD16): characterization and use in various assays." dans: Hybridoma, Vol. 16, Issue 6, pp. 519-28, (1998) (PubMed).

  • Antigène
    Fc gamma RII (CD32)
    Autre désignation
    CD32 (CD32 Produits)
    Synonymes
    anticorps CD32, anticorps CD32B, anticorps FCG2, anticorps FCGR2, anticorps IGFR2, anticorps FCGR2B, anticorps AI528646, anticorps F630109E10Rik, anticorps Fc[g]RII, anticorps FcgRII, anticorps Fcgr2, anticorps Fcgr2a, anticorps Fcr-2, anticorps Fcr-3, anticorps Ly-17, anticorps Ly-m20, anticorps LyM-1, anticorps Lym-1, anticorps FCRII, anticorps FcRII, anticorps Fc fragment of IgG receptor IIb, anticorps Fc receptor, IgG, low affinity IIb, anticorps FCGR2B, anticorps Fcgr2b
    Sujet
    Fc fragment of IgG receptor IIa,CD32 (FcgammaRII) is a low affinity receptor for aggregated IgG. It is strongly expressed on monocytes, granulocytes, myeloid and myeloblastic cell lines, and weakly on B cells, CD34+ bone marrow cells, and resting and activated platelets. After binding its ligand, CD32 induces IgG-mediated phagocytosis and oxidative burst in monocytes and neutrophils, whereas in B cells it mediates a negative signal. This polymorphic transmembrane glycoprotein is expressed not only in the activating (CD32a) and inhibitory isoform (CD32b), but also in individual variants with differing avidities for IgG subtypes (e.g. the CD32a131R and CD32a131H allotypes).,FCG2, FCGR2A, IGFR2
    ID gène
    2212
    UniProt
    P12318
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