CD160 anticorps (PE)

N° du produit ABIN1981901

Il existe 4+ publications pour ce produit. L’anticorps anti-CD160 Monoclonal Souris est utilisé pour la détection de CD160 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour CD160 anticorps (PE) (ABIN1981901)

Antigène: CD160

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD160 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: BY55

Détail du produit anti-CD160 anticorps (PE)

Fonction: Anti-Hu CD160 PE

Réactivité croisée (Details): Human

Attributs du produit: The mouse monoclonal antibody BY55 recognizes an extracellular epitope of CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. The antibody detects both GPI-anchored and transmembrane form of CD160.

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Human NK cell line YT2C2

Isotype: IgM, kappa

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze,Protect from prolonged exposure to light

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-CD160 (PE) (ABIN1981901)

Giustiniani, Bensussan, Marie-Cardine: "Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 1, pp. 63-71, (2008) (PubMed).

Merino, Ramírez, Moreno, Toledo, Fernández, Sánchez-Ibarrola: "BY55/CD160 cannot be considered a cytotoxic marker in cytomegalovirus-specific human CD8(+) T cells." dans: Clinical and experimental immunology, Vol. 149, Issue 1, pp. 87-96, (2007) (PubMed).

Anumanthan, Bensussan, Boumsell, Christ, Blumberg, Voss, Patel, Robertson, Nadler, Freeman: "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 6, pp. 2780-90, (1998) (PubMed).

Bensussan, Gluckman, el Marsafy, Schiavon, Mansur, Dausset, Boumsell, Carosella: "BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 19, pp. 9136-40, (1994) (PubMed).

Détails sur CD160

Antigène: CD160

Autre désignation: CD160

Sujet: CD160 Molecule,CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.,NK1, NK28

ID gène: 11126

UniProt: O95971