HPV16 E7 anticorps (Middle Region)

N° du produit ABIN2173795

Cet anticorps Lapin Polyclonal détecte spécifiquement HPV16 E7 dans WB, IF (p), ELISA, FACS, IF (cc), IHC (p), IHC (fro) et ICC. Il présente une réactivité envers Human Papillomavirus 16 (HPV-16) et a été mentionné dans 2+ publications.

Aperçu rapide pour HPV16 E7 anticorps (Middle Region) (ABIN2173795)

Antigène: HPV16 E7 (HPV-16 E7) (Human Papilloma Virus 16 E7 (HPV-16 E7))

Reactivité: Human Papillomavirus 16 (HPV-16)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HPV16 E7 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Détail du produit anti-HPV16 E7 anticorps

Épitope: Middle Region

Specificité: This antibody may also detect HPV35-E7

Réactivité croisée: Humain, Virus

Réactivité croisée (Details): HPV16

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from middle of HPV16-E7

Isotype: IgG

Information d'application

Indications d'application: WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-HPV16 E7 (ABIN2173795)

Liu, Murray-Stewart, Casero, Kagiampakis, Jin, Zhang, Wang, Che, Tong, Ke, Jiang, Wang, Wan: "Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth." dans: International journal of oncology, Vol. 50, Issue 6, pp. 2011-2023, (2017) (PubMed).

Shao, Sun, Wang, Chung, Du, Wang, Qiu, Wang, Wu: "HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells." dans: Tumour biology, Vol. 39, Issue 7, pp. 1010428317717140, (2017) (PubMed).

Détails sur HPV16 E7

Antigène: HPV16 E7 (HPV-16 E7) (Human Papilloma Virus 16 E7 (HPV-16 E7))

Classe de substances: Viral Protein

Sujet:

Synonyms: Protein E7, E7

Background: Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.

ID gène: 1489079

UniProt: P03129