HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd) (AA 331-430) anticorps (FITC)

N° du produit ABIN2175625

Cet anticorps Lapin Polyclonal détecte spécifiquement dans WB, IF (cc) et IF (p). Il présente une réactivité envers Humain.

Aperçu rapide pour HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd) (AA 331-430) anticorps (FITC) (ABIN2175625)

Antigène: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit

Épitope: AA 331-430

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Syncytin-2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Autre désignation: Herv-Frd

Sujet:

Synonyms: envFRD, UNQ6191, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, Syncytin-2, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD_6p24.1 provirus ancestral Env polyprotein, ERVFRD-1, UNQ6191/PRO20218

Background: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).

ID gène: 405754

UniProt: P60508