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Mbl1 anticorps

Mbl1 Reactivité: Souris WB, IF, IA, FACS Hôte: Rat Monoclonal 8G6 unconjugated
N° du produit ABIN2191773
  • Antigène Voir toutes Mbl1 Anticorps
    Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))
    Reactivité
    Souris
    Hôte
    • 2
    • 1
    • 1
    Rat
    Clonalité
    • 2
    • 2
    Monoclonal
    Conjugué
    • 4
    Cet anticorp Mbl1 est non-conjugé
    Application
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoassay (IA), Flow Cytometry (FACS)
    Stérilité
    0.2 μm filtered
    Clone
    8G6
  • Indications d'application
    For immunohistochemistry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    Restrictions
    For Research Use only
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Held, Thiel, Loos, Petry: "Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans." dans: Molecular immunology, Vol. 45, Issue 15, pp. 3934-41, (2008) (PubMed).

    Petry, Jakobi, Wagner, Tessema, Thiel, Loos: "Binding and activation of human and mouse complement by Cryptosporidium parvum (Apicomplexa) and susceptibility of C1q- and MBL-deficient mice to infection." dans: Molecular immunology, Vol. 45, Issue 12, pp. 3392-400, (2008) (PubMed).

    Abe, Kuroda, Kuboki, Matsushita, Yokoyama, Kojima: "Contribution of complement component C3 and complement receptor type 3 to carbohydrate-dependent uptake of oligomannose-coated liposomes by peritoneal macrophages." dans: Journal of biochemistry, Vol. 144, Issue 5, pp. 563-70, (2008) (PubMed).

    Windbichler, Echtenacher, Takahashi, Ezekowitz, Schwaeble, Jenseniuis, Männel: "Investigations on the involvement of the lectin pathway of complement activation in anaphylaxis." dans: International archives of allergy and immunology, Vol. 141, Issue 1, pp. 11-23, (2006) (PubMed).

    Liu, Jensen, Hansen, Petersen, Takahashi, Ezekowitz, Hansen, Jensenius, Thiel: "Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses." dans: Scandinavian journal of immunology, Vol. 53, Issue 5, pp. 489-97, (2001) (PubMed).

  • Antigène
    Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))
    Autre désignation
    Mannose Binding Lectin A (Mbl1 Produits)
    Synonymes
    anticorps MBL-A, anticorps MBP-A, anticorps pMBP-28, anticorps S-MBP, anticorps Mbpa, anticorps Mlb1, anticorps mannan-binding lectin (A), anticorps mannose-binding lectin (protein A) 1, anticorps MBL1, anticorps Mbl1
    Sujet
    Mannose Binding Lectin (MBL), also called mannosebinding protein (MBP), is a calcium dependent oligomeric protein that belongs to the collectin family of proteins. It contains a collagen-like domain and a carbohydrate recognition domain enabling MBL to recognize carbohydrates (such as mannose and N-acetylglucosamine) on pathogens. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways, by using attached mannose binding lectin-associated serine proteases (MASP-2) in an antibody- and C1q-independent manner. MASP-2 permits cleavage of C4 and C2 to form a C3 convertase. Once it has bound, MBL exhibits complement-dependent antibacterial activities such as microbial opsonization and/or microbial lysis via membrane attack complexes and therefore plays an important role in innate immunity. In human, MBL is encoded by a single gene, whereas in mice there are two homologous proteins, termed MBL-A and MBL-C. The MBL-A concentration in serum is about 6-fold lower compared to that of MBL-C... MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS- injection models. Moreover, it has been shown that MBL-A deficient mice have aberrant antigen- specific IgM responses and suffer from increased susceptibility to infection . Note that the monoclonal antibody 8G6 is a calcium-dependent antibody. Aliases Mannose binding protein A, MBP-A, Ra-reactive factor polysaccharide-binding component p28B, RaRF p28B, MBL-1 Immunogen Purified mouse MBL-A,
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