JAM3 anticorps

N° du produit ABIN2191806

Cet anticorps anti-JAM3 est un anticorps Rat Monoclonal détectant JAM3 dans IP, FACS, IHC (fro) et IA. Adapté pour Souris. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour JAM3 anticorps (ABIN2191806)

Antigène: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp JAM3 est non-conjugé

Application: Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)

Clone: CRAM-19 H36

Détail du produit anti-JAM3 anticorps

Stérilité: 0.2 μm filtered

Information d'application

Indications d'application: For immunohistology and flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-JAM3 (ABIN2191806)

Johnson-Léger, Aurrand-Lions, Beltraminelli, Fasel, Imhof: "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration." dans: Blood, Vol. 100, Issue 7, pp. 2479-86, (2002) (PubMed).

Détails sur JAM3

Antigène: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Autre désignation: Junctional Adhesion Molecule-C

Sujet: Junctional adhesion molecule-C (JAM-C) also known as JAM-2 is a 45 kD cell adhesion molecule (CAM). JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. Monoclonal antibody CRAM-19 H36 also reacts with human JAM-C. In humans, JAM-C expression is not restricted to endothelial cells, but is also expressed on human lymphocytes.