CD13 anticorps

N° du produit ABIN2191832

Détail du produit anti-CD13 anticorps

Antigène: CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD13 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Stérilité: 0.2 μm filtered

Clone: ER-BMDM1

Information d'application

Indications d'application: For immunohistology and flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-CD13 (ABIN2191832)

Leenen, Radosevi?, Voerman, Salomon, van Rooijen, Klatzmann, van Ewijk: "Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2166-73, (1998) (PubMed).

Allaerts, Salomon, Leenen, van Wijngaardt, Jeucken, Ruuls, Klatzmann, Drexhage: "A population of interstitial cells in the anterior pituitary with a hematopoietic origin and a rapid turnover: a relationship with folliculo-stellate cells?" dans: Journal of neuroimmunology, Vol. 78, Issue 1-2, pp. 184-97, (1997) (PubMed).

Leenen, Melis, Kraal, Hoogeveen, Van Ewijk: "The monoclonal antibody ER-BMDM1 recognizes a macrophage and dendritic cell differentiation antigen with aminopeptidase activity." dans: European journal of immunology, Vol. 22, Issue 6, pp. 1567-72, (1992) (PubMed).

Détails sur CD13

Antigène: CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Abstract: ANPEP Produits

Synonymes: anticorps APN, anticorps CD13, anticorps GP150, anticorps LAP1, anticorps P150, anticorps PEPN, anticorps A2AP, anticorps AAP, anticorps ALPHA-2-PI, anticorps API, anticorps PLI, anticorps AAT1, anticorps ALT1, anticorps GPT1, anticorps Gpt1, anticorps Apn, anticorps pepN, anticorps SC8E4A.13, anticorps 1300007J06Rik, anticorps 2310022B03Rik, anticorps ALT, anticorps Gpt-1, anticorps AP-M, anticorps AP-N, anticorps Cd13, anticorps Apm, anticorps KZP, anticorps Lap1, anticorps rAPN, anticorps APDE, anticorps p150, anticorps anpep, anticorps fb64c05, anticorps wu:fb64c05, anticorps zgc:136771, anticorps alanyl aminopeptidase, membrane, anticorps serpin family F member 2, anticorps glutamic--pyruvic transaminase, anticorps aminopeptidase N, anticorps aminopeptidase, anticorps aminopeptidase n, anticorps glutamic pyruvic transaminase, soluble, anticorps alanyl (membrane) aminopeptidase, anticorps membrane alanyl aminopeptidase, anticorps alanyl (membrane) aminopeptidase b, anticorps alanyl aminopeptidase, membrane L homeolog, anticorps ANPEP, anticorps SERPINF2, anticorps GPT, anticorps Gpt, anticorps Apn2, anticorps Apn1, anticorps SCO2643, anticorps pepN, anticorps Shewana3_0897, anticorps Alvin_1024, anticorps Ndas_3413, anticorps Saut_1544, anticorps Fbal_1877, anticorps ML5_3424, anticorps Despr_1988, anticorps Mesop_5365, anticorps Anpep, anticorps LOC101744250, anticorps anpepb, anticorps anpep.L

Sujet: The monoclonal antibody ER-BMDM1 is directed against a 160- kDa cell membrane-associated antigen with aminopeptidase N activity. Aminopeptidase N (APN) is also known as Alanyl Aminopeptidase (ANPEP), CD13 antigen or membrane protein p161. The protein consists of a short cyplasmic tail, a transmembrane region, a Ser/Thr region, and a zinc metalloproteinase domain. Widely expressed in many cells, tissues, and species, aminopeptidase N cleaves the N-terminal amino acids from bioactive peptides, leading to their inactivation or degradation. It has putative involvement in several biological processes including antigen processing and presentation, cell adhesion, tumor invasion and metastasis and neurotransmitter degradation. The antigen recognized by the mocnoclonal antibody ER-BMDM1 is present on various mouse macrophage and dendritic cell subpopulations as well as on microvillous epithelia. The ER-BMDM1 antigen is expressed at increasing levels upon maturation of macrophages. Therefore the monoclonal antibody ER-BMDM1 is a useful marker for the identification of aminopeptidase N positive macrophages and dendritic cells in mouse, the expression of the ER- BMDM1 antigen arises after the monocytic stage of differentation: bone marrow cells and peripheral blood monocytes are ER-BMDM1 negative, whereas mature macrophages express the ER-BMDM1 antigen. A subpopulation of dendrocytes and their in vitro equivalents, the dendritic cells, are also ER- BMDM1 positive.

Pathways: Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones