ICAM1 anticorps

N° du produit ABIN2191981

Cet anticorps Souris Monoclonal détecte spécifiquement ICAM1 dans FACS, IP, IHC (p), IHC (fro), StM et IA. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour ICAM1 anticorps (ABIN2191981)

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ICAM1 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Staining Methods (StM), Immunoassay (IA)

Clone: HM-2

Détail du produit anti-ICAM1 anticorps

Stérilité: 0.2 μm filtered

Information d'application

Indications d'application: For immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-ICAM1 (ABIN2191981)

van de Stolpe, van der Saag: "Intercellular adhesion molecule-1." dans: Journal of molecular medicine (Berlin, Germany), Vol. 74, Issue 1, pp. 13-33, (1996) (PubMed).

Sligh, Ballantyne, Rich, Hawkins, Smith, Bradley, Beaudet: "Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 18, pp. 8529-33, (1993) (PubMed).

Détails sur ICAM1

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Sujet: The monoclonal HM.2 antibody reacts with the 90 kD glycoprotein Intracellular Adhesion Molecule-1 (ICAM-1). The adhesion molecule ICAM-1 belongs to the immunoglobulin superfamily, C2 subset, it is a ligand for the Integrins LFA-1 and MAC-1 and for CD43. ICAM-1 is an essential component in many immune-related processes. ICAM-1 links with receptors of the integrin family, thereby mediating cell-cell interactions and allowing for signal transduction. ICAM-1 interacts specifically with its receptors to induce a reversible adhesion interaction. For processes like T cell activation and leucocyte recruitment, normal immune function relies on ICAM-1. Therefore, it is understandable that alterations in ICAM-1 structure or expression are associated with immune disorders. It is important to properly understand the various functions and regulatory mechanisms of ICAM-1, the resulting disease-related failures, and the various treatments. ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) and is expressed by the vascular endothelium, macrophages and lymphocytes Aliases ICAM-1, CD54

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling