PROS1 anticorps

N° du produit ABIN2192011

Détail du produit anti-PROS1 anticorps

Antigène: PROS1 (PROS) (Protein S (PROS))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp PROS1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Stérilité: 0.2 μm filtered

Clone: PS7

Information d'application

Indications d'application: For flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Détails sur PROS1

Antigène: PROS1 (PROS) (Protein S (PROS))

Autre désignation: Protein S (PROS Produits)

Synonymes: anticorps PROS, anticorps PS21, anticorps PS22, anticorps PS23, anticorps PS24, anticorps PS25, anticorps PSA, anticorps THPH5, anticorps THPH6, anticorps zgc:154001, anticorps AW214361, anticorps protein S, anticorps protein S (alpha), anticorps PROS1, anticorps Pros1, anticorps pros1

Sujet: Monoclonal antibody PS7 is specific for human Protein S (PS), a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 70 kDa. In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain. Monoclonal antibody PS7 allows specific detection of cells carrying PS by flow cytometry. Aliases PROS1