Myeloperoxidase anticorps

N° du produit ABIN2192023

Cet anticorps Souris Monoclonal détecte spécifiquement Myeloperoxidase dans WB et IA. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour Myeloperoxidase anticorps (ABIN2192023)

Antigène: Myeloperoxidase (MPO)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Myeloperoxidase est non-conjugé

Application: Western Blotting (WB), Immunoassay (IA)

Clone: 266-6K1

Détail du produit anti-Myeloperoxidase anticorps

Réactivité croisée (Details): Cross reactivity: Rat : No, Mouse : No

Stérilité: 0.2 μm filtered

Isotype: IgG1

Information d'application

Indications d'application: For Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive Neutrophils, HL-60 cells control Negative Erythocytes control

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Références pour anticorps anti-Myeloperoxidase (ABIN2192023)

La Rocca, Di Stefano, Eleuteri, Anzalone, Magno, Corrao, Loria, Martorana, Di Gangi, Colombo, Sansone, Patanè, Farina, Rinaldi, Cappello, Giannuzzi, Zummo: "Oxidative stress induces myeloperoxidase expression in endocardial endothelial cells from patients with chronic heart failure." dans: Basic research in cardiology, Vol. 104, Issue 3, pp. 307-20, (2009) (PubMed).

Détails sur Myeloperoxidase

Antigène: Myeloperoxidase (MPO)

Autre désignation: Myeloperoxidase

Sujet: The monoclonal antibody 266-6K1 recognizes human myeloperoxidase (MPO), an ~135 glycoprotein expressed in all cells of the myeloid linage. MPO functions as an α2β2 heteromultimer consisting of two heavy (α) and two light (β) chains of 55 and 15 kDa respectively. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils (PMNs). It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Upon activation of neutrophils, MPO can be rapidly released and as such useful in body fluids as marker for inflammatory status. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease, inflammatory bowel disease and multiple sclerosis. Autoimmune antibodies to MPO (so called ANCA) are involved in Wegener's disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has attracted more clinical attention.

Pathways: Chromatin Binding