Secretory Leucocyte Protease Inhibitor anticorps

N° du produit ABIN2192189

L’anticorps Lapin Polyclonal anti- a été validé pour IA, IP et WB. Il convient pour détecter dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour Secretory Leucocyte Protease Inhibitor anticorps (ABIN2192189)

Antigène: Secretory Leucocyte Protease Inhibitor

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Application: Immunoassay (IA), Immunoprecipitation (IP), Western Blotting (WB)

Détail du produit

Stérilité: 0.2 μm filtered

Information d'application

Indications d'application: For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Référence

Kramps, van Twisk, Klasen, Dijkman: "Interactions among stimulated human polymorphonuclear leucocytes, released elastase and bronchial antileucoprotease." dans: Clinical science (London, England : 1979), Vol. 75, Issue 1, pp. 53-62, (1988) (PubMed).

Détail du antigène

Antigène: Secretory Leucocyte Protease Inhibitor

Sujet: The antibody reacts with secretory leukocyte proteinase inhibitor (SLPI, also known as antileukoprotease (ALP)). SLPI is a 11.7 kDa cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs, by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulphide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).