ELANE anticorps

N° du produit ABIN2192191

Cet anticorps Lapin Polyclonal détecte spécifiquement ELANE dans IA. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour ELANE anticorps (ABIN2192191)

Antigène: ELANE (Elastase, Neutrophil Expressed (ELANE))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ELANE est non-conjugé

Application: Immunoassay (IA)

Détail du produit anti-ELANE anticorps

Stérilité: 0.2 μm filtered

Information d'application

Indications d'application: The antibody can be used in immuno assays. The antibody is not useful in immuno histology.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-ELANE (ABIN2192191)

Hiltermann, Lapperre, van Bree, Steerenberg, Brahim, Sont, Sterk, Hiemstra, Stolk: "Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: a new noninvasive tool in epidemiologic studies on air pollution and asthma." dans: Free radical biology & medicine, Vol. 27, Issue 11-12, pp. 1448-54, (2000) (PubMed).

Dentener, Francot, Hiemstra, Tool, Verhoeven, Vandenabeele, Buurman: "Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha." dans: The Journal of infectious diseases, Vol. 175, Issue 1, pp. 108-17, (1997) (PubMed).

Détails sur ELANE

Antigène: ELANE (Elastase, Neutrophil Expressed (ELANE))

Autre désignation: Leukocyte Elastase

Sujet: Leukocyte elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils and monocytes. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1- PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition mucosa secretions may contain the locally secreted elastase inhibitors elafin/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for human elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4.