THRA anticorps (N-Term)

N° du produit ABIN233838

Détail du produit anti-THRA anticorps

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THRA est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: This product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with human THRA protein.  A BLAST analysis was used to suggest cross-reactivity with THRA from mouse, human and rat based on a 100% homology with the immunizing sequence.  Cross-reactivity with THRA from other sources has not been determined.

Attributs du produit: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodo-thyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 co-activators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. This antibody recognizes THRA isoform 1. Isoform 1 has a distinct C-terminus compared to isoform 2.

Purification: affinity purified

Stérilité: Sterile filtered

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human THRA isoform 1 protein.
Immunogen Type: Peptide

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and western blotting.

Commentaires:

Gene Name: THRA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.89 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.

Date de péremption: 3 months

Références pour anticorps anti-THRA (ABIN233838)

Contreras-Jurado, García-Serrano, Martínez-Fernández, Ruiz-Llorente, Paramio, Aranda: "Impaired hair growth and wound healing in mice lacking thyroid hormone receptors." dans: PLoS ONE, Vol. 9, Issue 9, pp. e108137, (2015) (PubMed).

Mishra, Zhu, Ge, Cheng: "Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms." dans: Journal of molecular endocrinology, Vol. 44, Issue 4, pp. 247-55, (2010) (PubMed).

Détails sur THRA

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Autre désignation: THRA (THRA Produits)

Synonymes: anticorps AR7, anticorps CHNG6, anticorps EAR7, anticorps ERB-T-1, anticorps ERBA, anticorps ERBA1, anticorps NR1A1, anticorps THRA1, anticorps THRA2, anticorps c-ERBA-1, anticorps C-ERBA-ALPHA, anticorps TRalpha, anticorps c-erba, anticorps erba, anticorps nr1a1-A, anticorps thra-A, anticorps thra1, anticorps TR[a]1, anticorps nr1a1, anticorps thra, anticorps thral, anticorps tra, anticorps tra1, anticorps wu:fb59g07, anticorps Thra1, anticorps 6430529J03Rik, anticorps AW259572, anticorps Erba, anticorps Nr1a1, anticorps Rvr, anticorps T3R[a], anticorps T3Ralpha, anticorps Thra2, anticorps C-ERBA ALPHA1, anticorps Thra, anticorps fTHRalphaA, anticorps nr1a1-a, anticorps thyroid hormone receptor, alpha, anticorps thyroid hormone receptor, alpha L homeolog, anticorps thyroid hormone receptor alpha a, anticorps thyroid hormone receptor alpha, anticorps thyroid hormone receptor alpha-A, anticorps THRA, anticorps thra.L, anticorps thraa, anticorps Thra, anticorps tr-alpha, anticorps LOC109641414

Sujet: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodo-thyronine.  THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone.  THRA interacts with NCOA3 and NCOA6 co-activators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants.  Isoform 1 has a distinct C-terminus compared to isoform 2.
Synonyms: Thyroid hormone receptor alpha Nuclear receptor subfamily 1 group A member 1 c-erbA-alpha c-erbA-1 V-erbA-related protein 7 EAR-7

ID gène: 7067, 40806160

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development