tau anticorps (pTyr18)

N° du produit ABIN2443721

Il existe 1 publication pour ce produit. L’anticorps anti-tau Monoclonal Souris est utilisé pour la détection de tau dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC et IF.

Aperçu rapide pour tau anticorps (pTyr18) (ABIN2443721)

Antigène: tau (tau Protein)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp tau est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 9G3

Détail du produit anti-tau anticorps

Épitope: AA 12-24, pTyr18

Fonction: Phospho-Tau (tyr 18) Mouse Monoclonal Antibody (9G3)

Specificité: The antibody recognizes the human Phospho-Tau protein at the tyrosine 18 phosphorylation site with no detectable cross-reactivity.

Purification: Protein G purified

Immunogène: Peptide

Isotype: IgG2a

Information d'application

Indications d'application: WB 1:1000-1:5000,IHC 1:1000-1:5000,IF 1:2000-1:5000

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: If reconstituted with deionized water in 100 μL: WB 1:1000-1:5000, IHC 1:1000-1:5000, IF 1:2000-1:5000. Optimal dilution has to be determined by the user.

Buffer: Lyophilized protein G purified in PBS pH 7.4

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Date de péremption: 24 months

Références pour anticorps anti-tau (ABIN2443721)

Tang, Fesharaki-Zadeh, Takahashi, Nies, Smith, Luo, Chyung, Chiasseu, Strittmatter: "Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy." dans: Acta neuropathologica communications, Vol. 8, Issue 1, pp. 96, (2020) (PubMed).

Détails sur tau

Antigène: tau (tau Protein)

Autre désignation: tau

Sujet:

Phosphorylated Tau

Tauopathies are a group of diverse dementias and movement disorders which have a common pathological feature in that they all display the presence of intracellular accumulation of abnormal filaments of Tau protein. While the abnormal phosphorylation of Tau on serine and threonine has been well established in the disease process, its phosphorylation on tyrosine 18 has only recently been described as present in Alzheimer's disease (AD) brain.

UniProt: P10636