APP anticorps (cleaved, ISEVKMD Motif)

N° du produit ABIN2443769

L’anticorps anti-APP Polyclonal Lapin est utilisé pour la détection de APP dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour APP anticorps (cleaved, ISEVKMD Motif) (ABIN2443769)

Antigène: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-APP anticorps

Épitope: cleaved, ISEVKMD Motif

Fonction: Amyloid precursor protein cleaved by caspase-6 Rabbit Polyclonal Antibody

Specificité: The antibody recognizes the sequence (ISEVKMD) in Amyloid precursor protein (APP).

Immunogène: ISEVKMD peptide

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: If reconstituted with deionized water in 50 μL: WB 1: 5000. Optimal dilution has to be determined by the user.

Buffer: Lyophilized serum

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Date de péremption: 24 months

Détails sur APP

Antigène: APP (Amyloid beta (A4) Precursor Protein (APP))

Autre désignation: Amyloid precursor protein

Sujet: Amyloid precursor protein (APP) functions as a cell surface receptor in the synapses of neurons and is implicated in neurite growth, neuronal adhesion, axonogenesis and cell mobility. APP is known as the precursor molecule whose proteolysis generates beta amyloid. Defects in APP are the cause of Alzheimer's disease type 1 and of amyloidosis cerebroarterial. Caspase activation has been found to have a central role in neuronal death and chronic neurodegenerations such as Huntington's, Parkinson's and Alzheimer's diseases. Proteolytic cleavage of specific substrates has also been demonstrated to be an important cellular event in the pathogenesis of AD and inhibition of cleavage of APP by caspase-6 was demonstrated to suppress synapse loss, dentate gyral atrophy, and memory loss.

UniProt: P10636

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour