HIV-1 (V2 (GP120)) anticorps

N° du produit ABIN2443779

Cet anticorps anti-HIV-1 (V2 (GP120)) Monoclonal Human (Clone 2158) (ABIN2443779) détecte spécifiquement HIV-1 (V2 (GP120)) dans ELISA et Neut. L’anticorps est réactif avec des échantillons de Human Immunodeficiency Virus (HIV).

Aperçu rapide pour HIV-1 (V2 (GP120)) anticorps (ABIN2443779)

Antigène: HIV-1 (V2 (GP120))

Reactivité: Human Immunodeficiency Virus (HIV)

Hôte: Human

Clonalité: Monoclonal

Application: ELISA, Neutralization (Neut)

Clone: 2158

Détail du produit

Fonction: HIV-1 (V2 (gp120)) Human Monoclonal Antibody (2158)

Specificité: The antibody recognizes the V2 loop of the HIV-1 protein gp120.

Purification: Protein G purified

Immunogène: A specific antibody against human HIV-1 (V2 (gp120)). This antibody was generated from HIV-infected individuals by a method based on the Epstein-Barr virus transformation of peripheral blood mononuclear cells (PBMCs) followed by fusion with heteromyeloma cells. The epitope for this antibody is discontinuous.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with deionized water. Optimal dilution has to be determined by the user.

Buffer: Lyophilized protein G purified in PBS pH 7.4

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Date de péremption: 24 months

Détail du antigène

Antigène: HIV-1 (V2 (GP120))

Classe de substances: Virus

Sujet: Of the two types of Human immunodeficiency virus (HIV) which have been characterized, HIV-1 is more infective and is prevalent globally. The HIV virion is encapsulated by a viral envelope that contains complexes of surface proteins, which are important for the virus to attach and fuse to infect target cells. A precursor molecule known as gp160 (glycoprotein 160) is cleaved by proteases into gp120 (glycoprotein 120) and gp41 (glycoprotein 41), glycoproteins that make up the envelope proteins of HIV. The gp120 protein is composed of five variable regions (V1-V5) which often form loop structures, and five constant regions (C1-C5). Neutralization resistance of HIV-1 viral isolates is thought to be mediated by the V1/V2 domain structure (variable regions 1 and 2 of HIV-1 gp120). This antibody, clone 2158, directed against the V2 loop of HIV-1 gp120, has been shown to neutralize HIV-1.

UniProt: Q6BBS3