UNC13D anticorps (N-Term)

N° du produit ABIN2443930

Cet anticorps Lapin Polyclonal détecte spécifiquement UNC13D dans WB et IP. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour UNC13D anticorps (N-Term) (ABIN2443930)

Antigène: UNC13D (Unc-13 Homolog D (UNC13D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNC13D est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-UNC13D anticorps

Épitope: AA 1-273, N-Term

Fonction: Munc13-4 Rabbit Polyclonal Antibody

Specificité: The antibody recognizes the N-terminal of the human Munc13-4 protein (aa 1-273).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: If reconstituted with deionized water in 50 μL: WB: 1:2000, IP: native conditions. Optimal dilution has to be determined by the user.

Buffer: Lyophilized serum

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Date de péremption: 24 months

Détails sur UNC13D

Antigène: UNC13D (Unc-13 Homolog D (UNC13D))

Autre désignation: Munc13-4

Sujet:

Protein unc-13 homolog D, hMunc13-4, UNC13D, FHL3, HLH3, HPLH3, Munc13-4, unc-13 homolog D

Protein unc-13 homolog D (Munc13-4) is involved in cytotoxic granule exocytosis in lymphocytes. It regulates the assembly of recycling of late endosomal structures which leads to the formation of an endosomal exocytic compartment. It also regulates Ca2+-dependent secretory lysosome exocytosis in mast cells. Munc13-4 is highly expressed in the spleen, thymus and leukocytes and to a lesser extent in the lung and placenta, brain, heart, skeletal muscle and kidney. Defects in Munc13-4 are the cause of familial HL type 3 (FHL3).

UniProt: Q70J99

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process