GLO1 anticorps (full length)

N° du produit ABIN2451990

Cité dans 3 publications. Cet anticorps anti-GLO1 Monoclonal Rat (Clone 6F10) (ABIN2451990) détecte spécifiquement GLO1 dans WB, ELISA, IF et IC. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour GLO1 anticorps (full length) (ABIN2451990)

Antigène: GLO1 (Glyoxalase I (GLO1))

Reactivité: Humain, Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp GLO1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunochromatography (IC)

Clone: 6F10

Détail du produit anti-GLO1 anticorps

Épitope: full length

Specificité: Specific to human, simian, and mouse glyoxalase I.

Réactivité croisée (Details): Not tested in other species.

Attributs du produit: The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Purification: Purified

Stérilité: Sterile filtered

Immunogène: Recombinant GST-fused mouse glyoxalase I (full length)

Isotype: IgG2b kappa

Information d'application

Indications d'application: 1. Western blotting: ~ 1,000
2. Immunocytochemistry
3. ELISA
Other applications are not tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Agent conservateur: Azide free

Stock: -20 °C/-80 °C

Stockage commentaire: -20 C (For long term storage: -70 C)

Références pour anticorps anti-GLO1 (ABIN2451990)

Hovatta, Tennant, Helton, Marr, Singer, Redwine, Ellison, Schadt, Verma, Lockhart, Barlow: "Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice." dans: Nature, Vol. 438, Issue 7068, pp. 662-6, (2005) (PubMed).

Chen, Wollmer, Hoerndli, Münch, Kuhla, Rogaev, Tsolaki, Papassotiropoulos, Götz: "Role for glyoxalase I in Alzheimer's disease." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 20, pp. 7687-92, (2004) (PubMed).

Junaid, Kowal, Barua, Pullarkat, Sklower Brooks, Pullarkat: "Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor." dans: American journal of medical genetics. Part A, Vol. 131, Issue 1, pp. 11-7, (2004) (PubMed).

Détails sur GLO1

Antigène: GLO1 (Glyoxalase I (GLO1))

Autre désignation: Glyoxalase 1 (GLO1)

Sujet: Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer's disease.

UniProt: Q9CPU0