POMT1 anticorps

N° du produit ABIN2458911

Détail du produit anti-POMT1 anticorps

Antigène: POMT1 (Protein-O-Mannosyltransferase 1 (POMT1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POMT1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human POMT1.

Information d'application

Indications d'application: POMT1 antibody can be used for detection of POMT1 by ELISA at 1:62500. POMT1 antibody can be used for detection of POMT1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store POMT1 antibody at -20 °C.

Détails sur POMT1

Antigène: POMT1 (Protein-O-Mannosyltransferase 1 (POMT1))

Autre désignation: POMT1 (POMT1 Produits)

Synonymes: anticorps LGMD2K, anticorps MDDGA1, anticorps MDDGB1, anticorps MDDGC1, anticorps RT, anticorps AI505244, anticorps protein O-mannosyltransferase 1, anticorps protein-O-mannosyltransferase 1, anticorps POMT1, anticorps Pomt1

Sujet: POMT1 is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K).O-mannosylation is an important protein modification in eukaryotes that is initiated by an evolutionarily conserved family of protein O-mannosyltransferases. POMT1 shares sequence similarity with protein O-mannosyltransferases of S. cerevisiae. In yeast, these enzymes are located in the endoplasmic reticulum (ER) and are required for cell integrity and cell wall rigidity. POMT1 also shows similarity to the Drosophila 'rotated abdomen' (rt) gene, which when mutated causes defects in myogenesis and muscle structure.

Poids moléculaire: 82 kDa

ID gène: 10585

NCBI Accession: NP_001070833

UniProt: B3KQG0