CTCF anticorps
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- Antigène Voir toutes CTCF Anticorps
- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
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Reactivité
- Humain, Souris, Rat, Chien
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CTCF est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- Antibody is purified by peptide affinity chromatography method.
- Immunogène
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CTCF.
- Top Product
- Discover our top product CTCF Anticorps primaire
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- Indications d'application
- CTCF antibody can be used for detection of CTCF by ELISA at 1:312500. CTCF antibody can be used for detection of CTCF by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Conseil sur la manipulation
- As with any antibody avoid repeat freeze-thaw cycles.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store CTCF antibody at -20 °C.
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- Antigène
- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
- Autre désignation
- CTCF (CTCF Produits)
- Synonymes
- anticorps im:7152666, anticorps CTCF, anticorps xctcf, anticorps AW108038, anticorps CCCTC-binding factor, anticorps CCCTC-binding factor (zinc finger protein), anticorps CTCF, anticorps ctcf, anticorps Ctcf
- Sujet
- CTCF is a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in CTCF have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.
- Poids moléculaire
- 83 kDa
- ID gène
- 10664
- NCBI Accession
- NP_006556
- UniProt
- P49711
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