MKRN1 anticorps

N° du produit ABIN2462668

Cet anticorps Lapin Polyclonal détecte spécifiquement MKRN1 dans WB et ELISA. Il présente une réactivité envers Humain, Souris, Chien et Rat.

Aperçu rapide pour MKRN1 anticorps (ABIN2462668)

Antigène: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Reactivité: Humain, Souris, Chien, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MKRN1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MKRN1 anticorps

Purification: Antibody is purified by protein A chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MKRN1.

Information d'application

Indications d'application: MKRN1 antibody can be used for detection of MKRN1 by ELISA at 1:312500. MKRN1 antibody can be used for detection of MKRN1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store MKRN1 antibody at -20 °C.

Détails sur MKRN1

Antigène: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Autre désignation: MKRN1

Sujet: The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.

Poids moléculaire: 16 kDa, 17 kDa

ID gène: 23608

NCBI Accession: NP_038474

UniProt: Q9UHC7

Pathways: Chromatin Binding