MKRN1 anticorps
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- Antigène Voir toutes MKRN1 Anticorps
- MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))
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Reactivité
- Humain, Souris, Chien, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MKRN1 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- Antibody is purified by protein A chromatography method.
- Immunogène
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MKRN1.
- Top Product
- Discover our top product MKRN1 Anticorps primaire
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- Indications d'application
- MKRN1 antibody can be used for detection of MKRN1 by ELISA at 1:312500. MKRN1 antibody can be used for detection of MKRN1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Conseil sur la manipulation
- As with any antibody avoid repeat freeze-thaw cycles.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store MKRN1 antibody at -20 °C.
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- Antigène
- MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))
- Autre désignation
- MKRN1 (MKRN1 Produits)
- Synonymes
- anticorps MKRN1, anticorps MGC84269, anticorps mkrn1, anticorps Makorin-1, anticorps RNF61, anticorps RFP, anticorps makorin ring finger protein 1, anticorps E3 ubiquitin-protein ligase makorin-1, anticorps makorin ring finger protein 1 S homeolog, anticorps makorin, ring finger protein, 1, anticorps MKRN1, anticorps LOC100393879, anticorps mkrn1.S, anticorps Mkrn1
- Sujet
- The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
- Poids moléculaire
- 16 kDa, 17 kDa
- ID gène
- 23608
- NCBI Accession
- NP_038474
- UniProt
- Q9UHC7
- Pathways
- Chromatin Binding
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