FER anticorps (truncated)

N° du produit ABIN2464050

Détail du produit anti-FER anticorps

Antigène: FER (FER Tyrosine Kinase (FER))

Épitope: truncated

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FER est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: Ni-NTA purified truncated recombinant FER-His expressed in E. Coli strain BL21 (DE3).

Clone: 5D2C4-8D8C12

Isotype: IgG1

Information d'application

Indications d'application: Western Blot:1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: -20 °C

Stockage commentaire: FER monoclonal antibody can be stored at -20 °C, stable for one year.

Détails sur FER

Antigène: FER (FER Tyrosine Kinase (FER))

Autre désignation: FER (FER Produits)

Synonymes: anticorps FerT, anticorps PPP1R74, anticorps TYK3, anticorps Fer, anticorps Flk, anticorps Flk_retired, anticorps AV082135, anticorps C330004K01Rik, anticorps Fert, anticorps FER tyrosine kinase, anticorps fer (fms/fps related) protein kinase, anticorps FER, anticorps Fer

Sujet: FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.

ID gène: 2241

UniProt: P16591