ALAS1 anticorps (AA 480-530)

N° du produit ABIN2470088

L’anticorps anti-ALAS1 Polyclonal Lapin est utilisé pour la détection de ALAS1 dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour ALAS1 anticorps (AA 480-530) (ABIN2470088)

Antigène: ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALAS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ALAS1 anticorps

Épitope: AA 480-530

Purification: Protein G Column

Immunogène: ALAS1 antibody was raised against amino acids 480 - 530 of ALAS1 (Human).

Isotype: IgG

Information d'application

Indications d'application: ALAS1 antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, 0.2 % gelatin, 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store ALAS1 antibody at 4 °C for short term applications. For long term storage, aliquot and -20 °C.

Détails sur ALAS1

Antigène: ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))

Autre désignation: ALAS1

Sujet: ALAS-1 (EC 2.3.1.37) is a nuclear-encoded mitochondrial matrix enzymecatalyzing the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5 phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.

ID gène: 211

UniProt: P13196

Pathways: Regulation of Lipid Metabolism by PPARalpha