Cullin 3 anticorps (N-Term)

N° du produit ABIN2470220

L’anticorps anti-Cullin 3 Polyclonal Lapin est utilisé pour la détection de Cullin 3 dans des échantillons de Humain. Il a été validé pour WB, IHC, ELISA et IP.

Aperçu rapide pour Cullin 3 anticorps (N-Term) (ABIN2470220)

Antigène: Cullin 3 (CUL3)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cullin 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Détail du produit anti-Cullin 3 anticorps

Épitope: N-Term

Purification: Delipidation and Defibrination

Immunogène: Cullin 3 antibody was raised against amino acids 1-12 from the N-Terminus of Cullin 3 (Human).

Information d'application

Indications d'application: Cullin 3 antibody can be used in ELISA starting at 1:1000, and immunohistochemistry starting at 10 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 % Sodium azide

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store Cullin 3 antibody at 4 °C or -20 °C.

Détails sur Cullin 3

Antigène: Cullin 3 (CUL3)

Autre désignation: Cullin 3

Sujet: Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 3 is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul3 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul3 may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Unlike Cul1 and Cul2, Cul3 seems not to be a part of the SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Cul3 also interacts with RNF7 and is part of a complex with TIP120A/CAND1, Cyclin E and RBX1.

ID gène: 8452

UniProt: Q13618

Pathways: M Phase