Toxin A (AA 2123-2132) anticorps

N° du produit ABIN2476899

Détail du produit

Antigène: Toxin A

Épitope: AA 2123-2132

Reactivité: Clostridium difficile

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: ELISA

Specificité: This antibody is specific for Clostridium difficile Toxin A, a gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density, and the administration of antibiotics. Toxin A (TcdA) is a large exotoxin which is an essential virulence factor for C. difficile infection. TcdA has a molecular weight of 308kD and is a glucosyltransferase, which irreversibly inactivates the Ras family of small GTPases to disrupt many important signalling pathways.

Attributs du produit: Purified IgG

Purification: Purified

Immunogène: Synthetic peptide corresponding to the amino acids 2123-2132 of the native molecule conjugated to Keyhole limpet Haemocyanin. Peptide sequence: CTIDGKKYYFN

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 5.0 mg/mL

Référence

Voth, Ballard: "Clostridium difficile toxins: mechanism of action and role in disease." dans: Clinical microbiology reviews, Vol. 18, Issue 2, pp. 247-63, (2005) (PubMed).

Détail du antigène

Antigène: Toxin A

UniProt: P16154