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CRYAA anticorps (PerCP)

CRYAA Reactivité: Humain WB, ELISA, IF, ICC Hôte: Souris Monoclonal 1H3-B8 PerCP
N° du produit ABIN2481848
  • Antigène Voir toutes CRYAA Anticorps
    CRYAA (Crystallin, alpha A (CRYAA))
    Reactivité
    • 45
    • 17
    • 16
    • 3
    • 1
    Humain
    Hôte
    • 28
    • 17
    • 1
    Souris
    Clonalité
    • 28
    • 18
    Monoclonal
    Conjugué
    • 21
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CRYAA est conjugé à/à la PerCP
    Application
    • 34
    • 26
    • 16
    • 10
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Detects ~20 kDa. Does not cross-react with αB-crystallin, βL-crystallin, ΒH- crystallin, γ-crystallin, HSP25, HSP27 or HSP47 proteins.
     Réactivité croisée
    Boeuf (Vache), Humain, Souris, Rat
    Purification
    Protein G Purified
    Immunogène
    Native Alpha Crystallin
    Clone
    1H3-B8
    Isotype
    IgG1
    Top Product
    Discover our top product CRYAA Anticorps primaire
  • Indications d'application
    • WB (1:2000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    0.5 μg/ml was sufficient for detection of 100 ng purified alphaA crystalline by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.2, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    CRYAA (Crystallin, alpha A (CRYAA))
    Autre désignation
    Alpha A Crystallin (CRYAA Produits)
    Synonymes
    anticorps CRYA1, anticorps CTRCT9, anticorps HSPB4, anticorps AI323437, anticorps Acry-1, anticorps Crya-1, anticorps Crya1, anticorps DAcry-1, anticorps lop18, anticorps alpha-a-crystallin, anticorps cryaa-A, anticorps CRYAA, anticorps wu:fc06h04, anticorps zgc:92036, anticorps HspB4, anticorps crystallin alpha A, anticorps crystallin, alpha A, anticorps alphaA-crystallin, anticorps alpha-crystallin A chain-like, anticorps crystallin alpha A S homeolog, anticorps alpha-crystallin A chain, anticorps CRYAA, anticorps Cryaa, anticorps CpipJ_CPIJ005646, anticorps cryaa, anticorps LOC100384978, anticorps cryaa.S, anticorps LOC458589, anticorps LOC102724652
    Sujet
    The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8).
    ID gène
    1409
    NCBI Accession
    NP_000385
    UniProt
    P02489
    Pathways
    M Phase
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