ABCC8 anticorps (AA 1548-1582) (Biotin)

N° du produit ABIN2482995

Cet anticorps Souris Monoclonal détecte spécifiquement ABCC8 dans WB, IHC, ICC et IF. Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour ABCC8 anticorps (AA 1548-1582) (Biotin) (ABIN2482995)

Antigène: ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ABCC8 est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: S289-16

Détail du produit anti-ABCC8 anticorps (Biotin)

Épitope: AA 1548-1582

Specificité: Detects ~160 kDa. Does not cross-react with SUR2B.

Réactivité croisée: Hamster, Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1

Isotype: IgG1

Information d'application

Indications d'application:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN2482995 was sufficient for detection of SUR1 in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur ABCC8

Antigène: ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))

Autre désignation: SUR1

Sujet: Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2).

ID gène: 25559

NCBI Accession: NP_037171

UniProt: Q09429

Pathways: Negative Regulation of Hormone Secretion