NALCN anticorps (AA 1659-1738) (Biotin)

N° du produit ABIN2483029

L’anticorps Souris Monoclonal anti-NALCN a été validé pour WB, ICC et IF. Il convient pour détecter NALCN dans des échantillons de Rat.

Aperçu rapide pour NALCN anticorps (AA 1659-1738) (Biotin) (ABIN2483029)

Antigène: NALCN (Sodium Leak Channel, Non-Selective (NALCN))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NALCN est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: S187-7

Détail du produit anti-NALCN anticorps (Biotin)

Épitope: AA 1659-1738

Specificité: Detects ~200 kDa.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN

Isotype: IgG1

Information d'application

Indications d'application:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN2483029 was sufficient for detection of NALCN in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur NALCN

Antigène: NALCN (Sodium Leak Channel, Non-Selective (NALCN))

Autre désignation: NALCN

Sujet: NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.

ID gène: 266760

NCBI Accession: NP_705894

UniProt: Q6Q760