BCAN anticorps (AA 219-655) (Atto 488)

N° du produit ABIN2483309

Cet anticorps anti-BCAN est un anticorps Souris Monoclonal détectant BCAN dans WB, ICC et IF. Adapté pour Rat.

Aperçu rapide pour BCAN anticorps (AA 219-655) (Atto 488) (ABIN2483309)

Antigène: BCAN (Brevican (BCAN))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCAN est conjugé à/à la Atto 488

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: S294A-6

Détail du produit anti-BCAN anticorps (Atto 488)

Épitope: AA 219-655

Specificité: Detects ~140 kDa (and smaller due to proteolytic cleavage).

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 219-655 of rat Brevican

Isotype: IgG2b

Information d'application

Indications d'application:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN2483309 was sufficient for detection of Brevican in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur BCAN

Antigène: BCAN (Brevican (BCAN))

Autre désignation: Brevican

Sujet: Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.

ID gène: 25393

NCBI Accession: NP_001028837

UniProt: P55068

Pathways: Glycosaminoglycan Metabolic Process