Amyloid anticorps (APC)

N° du produit ABIN2486477

Détail du produit

Antigène: Amyloid

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: APC

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: Recognizes all types of amyloid oligomers. Appears to recog a peptide backbone epitope common to amyloid oligomers, but not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Réactivité croisée: Eucaryotes, Humain, Souris, Rat

Purification: Protein A Purified

Immunogène: Synthetic molecular mimic of soluble oligomers

Information d'application

Indications d'application:

• WB (1:200)
• IP (1:200)
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:200 dilution of ABIN2486477 was sufficient for detection of amyloid oligomers in 10 μg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détail du antigène

Antigène: Amyloid

Synonymes: anticorps amyloid beta precursor protein, anticorps App

Sujet: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).

ID gène: 8666

NCBI Accession: NM_000484

UniProt: P05067