Valproic Acid anticorps

N° du produit ABIN5610817

Détail du produit anti-Valproic Acid anticorps

Antigène: Valproic Acid

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Valproic Acid est non-conjugé

Application: Enzyme Immunoassay (EIA)

Purification: Protein G chromatography

Immunogène: Valproic acid conjugated to KLH

Clone: 801

Isotype: IgG1

Information d'application

Indications d'application: May be used in immunoassays to detect and quantitate valproic acid.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.2mg/mL (OD280nm)

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur Valproic Acid

Antigène: Valproic Acid

Abstract: Valproic Acid Produits

Classe de substances: Chemical

Sujet: Valproic acid, valproate sodium and divalproex belong to the group of medicines called anticonvulsants, used to control certain types of seizures in the treatment of epilepsy. Also, valproic acid relieves histone deacetylases (HDACs) dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic centre of HDACs. Most importantly, valproic acid induces differentiation of carcinoma cells, transformed haematopoietic progenitor cells and leukaemic blasts from acute myeloid leukaemia patients. Moreover, tumour growth and metastasis formation are significantly reduced in animal experiments. Therefore, valproic acid might serve as an effective drug for cancer therapy.