HCV E2 anticorps (AA 384-665)

N° du produit ABIN264627

Cet anticorps anti-HCV E2 Polyclonal Chèvre (ABIN264627) détecte spécifiquement HCV E2 dans WB, IF et EIA. L’anticorps est réactif avec des échantillons de Hepatitis C Virus (HCV).

Aperçu rapide pour HCV E2 anticorps (AA 384-665) (ABIN264627)

Antigène: HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))

Reactivité: Hepatitis C Virus (HCV)

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp HCV E2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-HCV E2 anticorps

Épitope: AA 384-665

Purification: Sodium Sulfate Precipitation and Ion-Exchange Chromatography.

Immunogène: Recombinant E2 (genotype 1a)

Information d'application

Indications d'application: Conjugation-ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 4-5 mg/mL (OD280nm, E0.1% = 1.4)

Buffer: 0.01 M PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative and no stabilizing proteins.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur HCV E2

Antigène: HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))

Autre désignation: HCV Envelope Glycoprotein E2

Classe de substances: Viral Protein

Sujet: Hepatitis C E2 is a virus envelope glycoprotein which forms a heterodimer with the E1 protein. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.Synonyms: Hepatitis C Virus NS1, gp68, gp70