ACP1 anticorps

N° du produit ABIN264957

Détail du produit anti-ACP1 anticorps

Antigène: ACP1 (Acid Phosphatase 1, Soluble (ACP1))

Reactivité: Humain, Rat, Souris, Boeuf (Vache)

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp ACP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificité: This antibody reacts to LMW Protein Tyrosine Phosphatase.

Purification: Purified

Immunogène: The human protein, HCPTPA was subcloned into pRSET to express a His6 N terminal fusion protein. This protein was expressed in E. coli and purified to homogeneity on Ni affinity matrix.

Isotype: IgG

Information d'application

Indications d'application: Western Blot. Immunoprecipitation: 1 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS, 0.08 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Détails sur ACP1

Antigène: ACP1 (Acid Phosphatase 1, Soluble (ACP1))

Autre désignation: ACP1 / LMW-PTPase (ACP1 Produits)

Synonymes: anticorps HAAP, anticorps 4632432E04Rik, anticorps AI427468, anticorps Acp-1, anticorps LMW-PTP, anticorps haap, anticorps lmw-ptp, anticorps ptp1a, anticorps xlptp1, anticorps im:6910498, anticorps zgc:110844, anticorps Acp1, anticorps ACYPI006806, anticorps ACP, anticorps ACPH, anticorps APH, anticorps Acph, anticorps CG7899, anticorps Dmel\\CG7899, anticorps DDBDRAFT_0189318, anticorps DDBDRAFT_0266663, anticorps DDB_0189318, anticorps DDB_0266663, anticorps ACP1, anticorps XLPTP1, anticorps acp1, anticorps acp1a, anticorps ptp1a-A, anticorps LMW-PTPase, anticorps acid phosphatase 1, anticorps acid phosphatase 1, soluble, anticorps Acid phosphatase 1, anticorps acid phosphatase 1 L homeolog, anticorps ACP1, anticorps Acp1, anticorps acp1, anticorps Acph-1, anticorps acp1.L

Sujet: Low molecular weight protein tyrosine phosphtases, including the human red cell phosphatase, HCPTP, are widely expressed cytosolic proteins of approximately 18 kDa that exist in distinct isoforms and are highly selective for phosphotyrosine over phosphoserine or phosphotyrosine. The HCPTP-A and HCPTP-B proteins expressed in human red cells and placenta are fast and slow forms of red cell acid phosphatase5. Like other tyrosine phosphatases, HCPTP is sensitive to inhibition by vanadate, and has a catalytic mechanism that involves formation of a cystinylphosphate intermediate6. The crystal structure of the bovine heart derived enzyme BHPTP shows a four-stranded central parallel b sheet with flanking a helices and an active site cysteine residue in the typical tyrosine phosphatase sequence context, CXXXXXR. Biological actions and cellular substrates have not been fully elucidated. It is expressed in a wide range of cell types, and structural homologues are expressed in yeast. A catalytically inactive LMW-PTP functions to promote cell division and binds to tyrosine-phosphorylated PDGF receptors1. The HCPTPA isoform interacts with receptor tyrosine kinases, EphB1 and VEGFR2 (flk-1) 2,4. Its overexpression inhibits VEGF-induced endothelial proliferation and migration, and its recruitment to EphB1 complexes is crucial to downstream signaling between EphB1 and integrins that mediate cell-matrix attachment3.Synonyms: Adipocyte acid phosphatase, HAAP, Low molecular weight cytosolic acid phosphatase, Low molecular weight phosphotyrosine protein phosphatase, Red cell acid phosphatase 1

ID gène: 52

NCBI Accession: NP_004291

UniProt: P24666