EDG4 anticorps (N-Term)

N° du produit ABIN265051

Détail du produit anti-EDG4 anticorps

Antigène: EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EDG4 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody recognizes Human EDG-4 / LPA2. Other species not tested.

Purification: Purified

Immunogène: Antibody raised against a unique synthetic peptide derived from the N-terminal of the human EDG4 protein.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 5 - 10 μg/mL, should be visualized using a high sensitivitysecondary/substrate system (i. e. Pierce's SuperSignal West Femto Maximum SensitivitySubstrate).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS, 0.08 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Références pour anticorps anti-EDG4 (ABIN265051)

Iwai, Koike, Ohshima, Miyatake, Uchiyama, Saeki, Ishii: "RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway." dans: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 22, Issue 10, pp. 1612-20, (2007) (PubMed).

Jayapal, Tay, Reghunathan, Zhi, Chow, Rauff, Melendez: "Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcepsilonRI-aggregation reveals a complex network of genes involved in inflammatory responses." dans: BMC genomics, Vol. 7, pp. 210, (2006) (PubMed).

Shida, Watanabe, Aoki, Hama, Kitayama, Sonoda, Kishi, Yamaguchi, Sasaki, Sako, Konishi, Arai, Nagawa: "Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer." dans: Laboratory investigation; a journal of technical methods and pathology, Vol. 84, Issue 10, pp. 1352-62, (2004) (PubMed).

Détails sur EDG4

Antigène: EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

Autre désignation: EDG-4 / LPAR2 (LPAR2 Produits)

Synonymes: anticorps EDG-4, anticorps EDG4, anticorps LPA-2, anticorps LPA2, anticorps lpa2, anticorps Gpbar1, anticorps Edg4, anticorps IPA2, anticorps Pbx4, anticorps RGD1561336, anticorps zgc:101053, anticorps lysophosphatidic acid receptor 2, anticorps lysophosphatidic acid receptor 2 S homeolog, anticorps G protein-coupled bile acid receptor 1, anticorps growth hormone releasing hormone receptor, anticorps lysophosphatidic acid receptor 2a, anticorps LPAR2, anticorps lpar2.S, anticorps GPBAR1, anticorps Lpar2, anticorps GHRHR, anticorps lpar2a

Sujet: EDG4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG4 is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 is expressed in testes, ovarian tumor and leukocyte containing tissues.Synonyms: EDG4, Ipa-2, LPAR2, Lysophosphatidic acid receptor 2, Lysophosphatidic acid receptor Edg-4, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4

ID gène: 9170

NCBI Accession: NP_004711

UniProt: Q9HBW0