Adiponectin Receptor 1 anticorps

N° du produit ABIN265109

L’anticorps anti-Adiponectin Receptor 1 Polyclonal Lapin est utilisé pour la détection de Adiponectin Receptor 1 dans des échantillons de Humain. Il a été validé pour WB et EIA.

Aperçu rapide pour Adiponectin Receptor 1 anticorps (ABIN265109)

Antigène: Adiponectin Receptor 1 (ADIPOR1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Adiponectin Receptor 1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-Adiponectin Receptor 1 anticorps

Specificité: This antibody recognizes Adiponectin Receptor 1.

Purification: Ammonium Sulfate Precipitation

Immunogène: Synthetic peptide derived from Human Adiponectin Receptor 1 protein.

Information d'application

Indications d'application: Western Blot: 5-10 μg/mL. Positive Control: Highly expressed in skeletal muscle. Expressed at intermediate level inbrain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Détails sur Adiponectin Receptor 1

Antigène: Adiponectin Receptor 1 (ADIPOR1)

Autre désignation: Adiponectin Receptor 1

Sujet: Alzheimer's disease (AD) is characterized by formation of plaques of amyloid beta peptide (Abeta). Autosomally-inherited AD had been shown only in connection with coding sequence mutations. Likely transcription factors whose mutation can cause loss of function are ADR1, MIG1, and PuF, and for gain of function, E12/E47, ITF-2, and RFX2. Adr1 controls the expression of genes required for ethanol, glycerol, and fatty acid utilization (in yeast). Adr1 can act directly on the promoters of ADH2, ACS1, GUT1, CTA1, and POT1. The yeast homolog of the AMP-activated protein kinase, Snf1, promotes Adr1 chromatin binding in the absence of glucose, and the protein phosphatase complex, Glc7.Reg1, represses its binding in the presence of glucose. A post-translational process is invloved in the regulation of Adr1 binding. Chromatin binding by Adr1 is not the only step in ADH2 transcription that is regulated by glucose repression, Adr1 can bind to chromatin in repressed conditions in the presence of hyperacetylated histones. In yeast, nuclear extracts prepared from glucose-repressed and glucosederepressed cells are equally capable of supporting miniAdr1-dependent transcription and pre-initiation complex formation.Synonyms: ADIPOR1, CGI-45, PAQR1, Progestin and adipoQ receptor family member I

ID gène: 51094

NCBI Accession: NP_001121159

UniProt: Q96A54

Pathways: AMPK Signaling