CERK anticorps
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- Antigène Voir toutes CERK Anticorps
- CERK (Ceramide Kinase (CERK))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CERK est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificité
- This antibody reacts to Ceramide Kinase.
- Purification
- Purified
- Immunogène
- Synthetic peptide derived from human ceramide kinase protein
- Top Product
- Discover our top product CERK Anticorps primaire
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- Indications d'application
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ELISA. Western Blot: 1 - 10 μg/mL. Positive Control: High level expression in heart, brain, skeletal muscle, kidney and liver.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- Phosphate buffered saline with 0.08 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- Antigène
- CERK (Ceramide Kinase (CERK))
- Autre désignation
- Ceramide Kinase (CERK Produits)
- Synonymes
- anticorps AI848610, anticorps D330016D08Rik, anticorps mKIAA1646, anticorps LK4, anticorps dA59H18.2, anticorps dA59H18.3, anticorps hCERK, anticorps CERK, anticorps si:ch211-162i19.1, anticorps MGC81777, anticorps CG16708, anticorps DCERK, anticorps Dcerk, anticorps Dmel\\CG16708, anticorps dcerk, anticorps ceramide kinase, anticorps ceramide kinase S homeolog, anticorps Ceramide kinase, anticorps Cerk, anticorps CERK, anticorps cerk, anticorps cerk.S, anticorps CpipJ_CPIJ003342, anticorps LOAG_11245, anticorps LOC5579301, anticorps Bm1_50005
- Sujet
- Sphingolipids, in addition to being structural components of membranes, regulate cell-cell and cell-substrate interactions, proliferation, and differentiation. Members of this diverse group of lipids have emerged as a novel class of signaling molecules that also regulate phagocytosis. The mechanisms by which sphingolipids exert these effects remain incompletely defined. More than a decade ago, it was found that ceramide can be phosphorylated to ceramide 1-phosphate (C1P). Ceramide kinase (CERK) and its phosphorylated product ceramide 1-phosphate (C1P) are central players in inflammation and cancer. The product of CERK activity, ceramide 1-phosphate (C1P), has been reported to have mitogenic effects. C1P is a direct activator of cytosolic phospholipase A2 and is involved in arachidonic acid release. CERK is a mediator of Ca2+-dependent degranulation in mast cells. In both arachidonic acid release and mast cell degranulation, the intracellular elevation of Ca2+ is a central event that acts as a regulatory mechanism of CERK activity. C1P is found in brain synaptic vesicles, and plays a role in regulating the secretion of neurotransmitters. CERK activity exists in HL-60 cells where the C1P is derived from ceramide released from sphingomyelin. The expressed kinase has specific ceramide phosphorylating activity. CERKs exist in a variety of cellular organisms, including plants, nematodes, insects, and vertebrates.Synonyms: Acylsphingosine kinase, KIAA1646, LK4, Lipid kinase 4, hCERK
- ID gène
- 64781
- NCBI Accession
- NP_073603
- UniProt
- Q8TCT0
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