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RNF216 anticorps (Isoform 1, N-Term)

RNF216 Reactivité: Souris WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN265155
  • Antigène Voir toutes RNF216 Anticorps
    RNF216 (Ring Finger Protein 216 (RNF216))
    Épitope
    • 9
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Isoform 1, N-Term
    Reactivité
    • 44
    • 31
    • 19
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 44
    Lapin
    Clonalité
    • 44
    Polyclonal
    Conjugué
    • 20
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RNF216 est non-conjugé
    Application
    • 22
    • 14
    • 14
    • 13
    • 9
    • 7
    • 2
    • 1
    Western Blotting (WB)
    Specificité
    This antibody detects TRIAD3A. Located in the cytoplasm, TRIAD3A is ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes (Ref.6).
    Purification
    Purified
    Immunogène
    Peptide corresponding to 15 amino acids near the amino-terminus of Mouse TRIAD3A
    Isotype
    IgG
    Top Product
    Discover our top product RNF216 Anticorps primaire
  • Indications d'application
    Western Blot: 0.5-1.0 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate buffered saline with 0.02 % Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody (in aliquots) at -20 °C. Can be shipped at 2-8 °C.
  • Antigène
    RNF216 (Ring Finger Protein 216 (RNF216))
    Autre désignation
    RNF216 (RNF216 Produits)
    Synonymes
    anticorps RGD1565135, anticorps TRIAD3, anticorps RNF216, anticorps zin, anticorps u7i1, anticorps triad3, anticorps ubce7ip1, anticorps MGC147026, anticorps 2810055g22rik, anticorps 2810055G22Rik, anticorps AI647468, anticorps AU019462, anticorps C86502, anticorps F830018F18Rik, anticorps UIP83, anticorps Ubce7ip1, anticorps CAHH, anticorps U7I1, anticorps UBCE7IP1, anticorps ZIN, anticorps ring finger protein 216, anticorps Rnf216, anticorps RNF216, anticorps rnf216
    Sujet
    Activation of NF-?B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2). Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR (3,4). Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase (5). TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9, this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation (5).Synonyms: E3 ubiquitin-protein ligase RNF216, RING finger protein 216, TRIAD3, Triad domain-containing protein 3, UBCE7IP1, Ubiquitin-conjugating enzyme 7-interacting protein 1, ZIN, Zinc finger protein inhibiting NF-kappa-B
    ID gène
    54476
    NCBI Accession
    NP_996994
    UniProt
    Q9NWF9
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