RNF216 anticorps (Isoform 1, N-Term)

N° du produit ABIN265155

Cet anticorps anti-RNF216 Polyclonal Lapin (ABIN265155) détecte spécifiquement RNF216 dans WB. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour RNF216 anticorps (Isoform 1, N-Term) (ABIN265155)

Antigène: RNF216 (Ring Finger Protein 216 (RNF216))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF216 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RNF216 anticorps

Épitope: Isoform 1, N-Term

Specificité: This antibody detects TRIAD3A. Located in the cytoplasm, TRIAD3A is ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes (Ref.6).

Purification: Purified

Immunogène: Peptide corresponding to 15 amino acids near the amino-terminus of Mouse TRIAD3A

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 0.5-1.0 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C. Can be shipped at 2-8 °C.

Détails sur RNF216

Antigène: RNF216 (Ring Finger Protein 216 (RNF216))

Autre désignation: RNF216

Sujet: Activation of NF-?B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2). Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR (3,4). Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase (5). TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9, this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation (5).Synonyms: E3 ubiquitin-protein ligase RNF216, RING finger protein 216, TRIAD3, Triad domain-containing protein 3, UBCE7IP1, Ubiquitin-conjugating enzyme 7-interacting protein 1, ZIN, Zinc finger protein inhibiting NF-kappa-B

ID gène: 54476

NCBI Accession: NP_996994

UniProt: Q9NWF9