SPARC anticorps

N° du produit ABIN265179

Cet anticorps anti-SPARC Polyclonal Lapin (ABIN265179) détecte spécifiquement SPARC dans WB, IHC (fro) et EIA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour SPARC anticorps (ABIN265179)

Antigène: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPARC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Détail du produit anti-SPARC anticorps

Specificité: This antibody detects Human SPARC. May cross react with SPARCL1.

Purification: Antigen Immunoaffinity Chromatography

Immunogène: Synthetic peptide derived from the Human SPARC protein

Information d'application

Indications d'application: ELISA. Western Blot: 0.5-1 μg/mL. Positive control: mouse heart lysate. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.274 mg/mL

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon arrival freeze at -20 °C to -70 °C.

Détails sur SPARC

Antigène: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Autre désignation: SPARC / Osteonectin

Sujet: SPARC is a key factor in cell-matrix interactions and possibly tumour aggressiveness. The SPARC gene, which encodes a multifunctional glycoprotein with roles in tissue development, remodelling and fibrosis. A regulator of cell-extracellular matrix (ECM) interactions, SPARC represents a major factor in the ECM remodelling occurring during tumour invasion. in silico analysis reveals 4 UTR-SNPs located in the 3 -UTR of the SPARC gene, corresponding to 1474 g a, 1551 g c, 1922 t g and 2072 c t changes, which are significantly associated with tumoral state of the tissue. Of all hits, the 2072 SPARC polymorphism had the best association with cancer. SPARC therefore is a gene involved in a number of diseases including rheumatoid arthritis, scleroderma, tumor development and metastasis. SPARC variants have been detected in tumour samples of patients with acute myeloblastic leukemia (AML).Synonyms: BM-40, Basement-membrane protein 40, ON, Secreted protein acidic and rich in cysteine

ID gène: 6678

NCBI Accession: NP_003109

UniProt: P09486

Pathways: Autophagy