Netrin 1 anticorps

N° du produit ABIN265183

Cet anticorps Lapin Polyclonal détecte spécifiquement Netrin 1 dans WB. Il présente une réactivité avec des échantillons de Souris, Humain, Rat, Singe, Boeuf (Vache) et Cat.

Aperçu rapide pour Netrin 1 anticorps (ABIN265183)

Antigène: Netrin 1 (NTN1)

Reactivité: Souris, Humain, Rat, Singe, Boeuf (Vache), Cat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Netrin 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Netrin 1 anticorps

Specificité: This antibody detects Netrin 1.

Purification: Affinity Chromatography.

Immunogène: Synthetic peptide derived from the human Netrin 1 protein.

Isotype: IgG

Information d'application

Indications d'application: Western blot (0.05-0.5 μg/mL). Positive control: MDCKII cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C. Can be shipped at 2-8 °C.

Détails sur Netrin 1

Antigène: Netrin 1 (NTN1)

Autre désignation: Netrin-1

Sujet: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis. Netrin 1's main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.Synonyms: NTN1, NTN1L

ID gène: 9423

NCBI Accession: NP_004813

UniProt: O95631

Pathways: Regulation of Cell Size