CERS6 anticorps

N° du produit ABIN265213

Détail du produit anti-CERS6 anticorps

Antigène: CERS6 (Ceramide Synthase 6 (CERS6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CERS6 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects Lass6, widely expressed. Expressed in kidney, liver, brain, heart, placenta and lung.

Purification: Purified

Immunogène: Synthetic peptide dervied from human Lass6 protein

Information d'application

Indications d'application: Western blot (5-7 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Détails sur CERS6

Antigène: CERS6 (Ceramide Synthase 6 (CERS6))

Autre désignation: LASS6 (CERS6 Produits)

Synonymes: anticorps si:ch211-278b7.1, anticorps CERS6, anticorps CERS5, anticorps LASS6, anticorps 4732462C07Rik, anticorps AW544719, anticorps Lass6, anticorps T1L, anticorps RGD1561599, anticorps ceramide synthase 6, anticorps CERS6, anticorps cers6, anticorps Cers6

Sujet: Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.Synonyms: LAG1 longevity assurance homolog 6

ID gène: 253782

NCBI Accession: NP_982288

UniProt: Q6ZMG9