GUCY1B3 anticorps

N° du produit ABIN265451

L’anticorps Lapin Polyclonal anti-GUCY1B3 a été validé pour WB, IHC (p) et EIA. Il convient pour détecter GUCY1B3 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour GUCY1B3 anticorps (ABIN265451)

Antigène: GUCY1B3 (Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GUCY1B3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-GUCY1B3 anticorps

Specificité: This antibody detects endogenous levels of Guanylate Cyclase β1/3 protein. (region surrounding Val21)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 5000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur GUCY1B3

Antigène: GUCY1B3 (Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3))

Autre désignation: Guanylate Cyclase Soluble GUCY1B3

Sujet: Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.Synonyms: GCS-beta-1, GCS-beta-3, GUC1B3, GUCSB3, GUCY1B1, Guanylate cyclase soluble subunit beta-1, Guanylate cyclase soluble subunit beta-3, Soluble guanylate cyclase small subunit, sGC beta

Poids moléculaire: approx. 70 kDa

ID gène: 2983

NCBI Accession: NP_000848

UniProt: Q02153

Pathways: Transition Metal Ion Homeostasis