MMP3 anticorps

N° du produit ABIN265531

Détail du produit anti-MMP3 anticorps

Antigène: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects endogenous levels of MMP-3 protein. (region surrounding Ser453)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/10000approx. 1/20000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-MMP3 (ABIN265531)

Wiel, Gras, Vindrieux, Warnier, Gitenay, Le Calvé, Ferrand, Augert, Bernard: "Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape." dans: Oncogene, Vol. 35, Issue 12, pp. 1596-601, (2016) (PubMed).

Zhang, Lu, Ren, Du, Zheng, Ioannou, Holmgren: "Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1." dans: Free radical biology & medicine, Vol. 89, pp. 192-200, (2016) (PubMed).

Muto, Kokubu, Mifune, Inui, Harada, Yoshifumi, Takase, Kuroda, Kurosaka: "Temporary inductions of matrix metalloprotease-3 (MMP-3) expression and cell apoptosis are associated with tendon degeneration or rupture after corticosteroid injection." dans: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Vol. 32, Issue 10, pp. 1297-304, (2014) (PubMed).

Ma, Wu, Wang, Wang, Wu, Zhu, Zhao: "Effects of chronic sleep deprivation on the extracellular signal-regulated kinase pathway in the temporomandibular joint of rats." dans: PLoS ONE, Vol. 9, Issue 9, pp. e107544, (2014) (PubMed).

Papaconstantinou, Zeglinas, Gazouli, Nastos, Yiallourou, Lykoudis, Evangelou, Papalois, Papaioannou, Vlachogiannakos, Tzathas: "Effect of infliximab on the healing of intestinal anastomosis. An experimental study in rats." dans: International journal of surgery (London, England), Vol. 12, Issue 9, pp. 969-75, (2014) (PubMed).

Pasham, Pathare, Fajol, Rexhepaj, Michael, Pakladok, Alesutan, Rotte, Föller, Lang: "OSR1-sensitive small intestinal Na+ transport." dans: American journal of physiology. Gastrointestinal and liver physiology, Vol. 303, Issue 11, pp. G1212-9, (2012) (PubMed).

Yamakawa, Uchida, Matthay, Makita: "Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 300, Issue 4, pp. L516-25, (2011) (PubMed).

Fu, Chen, Cao, Luo, Qian, Yang, Ren, Su, Cao, Yang, Yan, Shen, Wu, Feng, Wang: "p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways." dans: Hepatology (Baltimore, Md.), Vol. 53, Issue 1, pp. 181-92, (2011) (PubMed).

Zhu, Gao, Qi, Hong, Li, Wang, McHepange, Zhang, Wei, Chen: "Local hyperthermia could induce antiviral activity by endogenous interferon-dependent pathway in condyloma acuminata." dans: Antiviral research, Vol. 88, Issue 2, pp. 187-92, (2010) (PubMed).

Détails sur MMP3

Antigène: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Autre désignation: MMP-3 (MMP3 Produits)

Synonymes: anticorps CHDS6, anticorps MMP-3, anticorps SL-1, anticorps STMY, anticorps STMY1, anticorps STR1, anticorps SLN-1, anticorps SLN1, anticorps STR-1, anticorps Stmy1, anticorps Str1, anticorps MMP10, anticorps chds6, anticorps mmp-3, anticorps mmp13, anticorps mmp3, anticorps sl-1, anticorps stmy, anticorps stmy1, anticorps str1, anticorps matrix metallopeptidase 3, anticorps matrix metallopeptidase 3 (stromelysin 1, progelatinase), anticorps matrix metallopeptidase 3 L homeolog, anticorps MMP3, anticorps Mmp3, anticorps mmp3.L

Sujet: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP3 is reported to be implicated in rheumatoid arthritis and some forms of cancer.Synonyms: MMP3, Matrix metalloproteinase-3, SL-1, STMY1, Stromelysin-1, Transin-1

Poids moléculaire: approx. 53 kDa

ID gène: 4314

NCBI Accession: NP_002413

UniProt: P08254