Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

CD172a/b anticorps (APC)

Reactivité: Humain ELISA, WB Hôte: Souris Monoclonal SE5A5 APC
N° du produit ABIN2656973
  • Antigène
    CD172a/b
    Reactivité
    Humain
    Hôte
    • 9
    Souris
    Clonalité
    • 9
    Monoclonal
    Conjugué
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    APC
    Application
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Purification
    The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    Clone
    SE5A5
    Isotype
    IgG1 kappa
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Protect from prolonged exposure to light. Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    The antibody solution should be stored undiluted between 2°C and 8°C
  • Antigène
    CD172a/b
    Sujet
    CD172a, also known as signal-regulatory protein α (SIRPα), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPα was recently demonstrated to be a specifc marker for cardiomyocytes derived from human pluripotent stem cells.2
Vous êtes ici:
Support technique