ICOS anticorps (Alexa Fluor 647)

N° du produit ABIN2657721

Cet anticorps Hamster Monoclonal détecte spécifiquement ICOS dans FACS et ICFC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ICOS anticorps (Alexa Fluor 647) (ABIN2657721)

Antigène: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Reactivité: Humain, Souris, Rat

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp ICOS est conjugé à/à la Alexa Fluor 647

Application: Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)

Clone: C398-4A

Détail du produit anti-ICOS anticorps (Alexa Fluor 647)

Réactivité croisée: Macaque rhésus, Porc

Purification: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C

Détails sur ICOS

Antigène: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Autre désignation: CD278

Sujet: ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.

Pathways: Cancer Immune Checkpoints