CCL17 anticorps (Biotin)

N° du produit ABIN2660891

Détail du produit anti-CCL17 anticorps (Biotin)

Antigène: CCL17 (Chemokine (C-C Motif) Ligand 17 (CCL17))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp CCL17 est conjugé à/à la Biotin

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

Clone: Poly5230

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CCL17

Antigène: CCL17 (Chemokine (C-C Motif) Ligand 17 (CCL17))

Autre désignation: CCL17 (CCL17 Produits)

Synonymes: anticorps A-152E5.3, anticorps ABCD-2, anticorps SCYA17, anticorps TARC, anticorps CCL17, anticorps Abcd-2, anticorps Scya17, anticorps Scya17l, anticorps Tarc, anticorps abcd2, anticorps C-C motif chemokine ligand 17, anticorps chemokine (C-C motif) ligand 17, anticorps ATP-binding cassette sub-family D member 2, anticorps CCL17, anticorps Ccl17, anticorps LOC100537809

Sujet: CCL17 was initially isolated from phytohemagglutinin-stimulated PBMCs. CCL17 is constitutively expressed in the thymus and, under activation, in several cell types. CCL17-mediated recruitment of Th2 cells and CLA+ CD4+ T cells plays a key role in allergic diseases like atopic dermatitis, allergic asthma, allergic rhinitis, and allergic contact dermatitis. In addition, CCL17 has been detected in idiopathic pulmonary fibrosis. Also, CCL17 and CCL22 secreted by dendritic cells seem to mediate the recruitment of regulatory T cells to sites of inflammation in patients with chronic hepatitis. CCL17 is upregulated by several combinations of cytokines: TNF-α, IL-4, and IFN-γ in bronchial epithelial cells, TGF-β1, TNF-α, and IFN-γ in human keratinocyte cell lines, and histamine and prostaglandin E2P in immature dendritic cells.