Integrin Alpha9 Beta1 (ITGA9/ITGB1) anticorps (PE)

N° du produit ABIN2662767

Détail du produit

Antigène: Integrin Alpha9 Beta1 (ITGA9/ITGB1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: PE

Application: Flow Cytometry (FACS)

Réactivité croisée: Cobaye

Purification: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: Y9A2

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détail du antigène

Antigène: Integrin Alpha9 Beta1 (ITGA9/ITGB1)

Autre désignation: Integrin Alpha9beta1

Sujet: Integrin α9β1 is a transmembrane protein belonging to the integrin family. It is widely expressed in airway epithelium, different types of muscle cells, and hepatocytes. In the hematopoietic system, integrin α9β1 is highly expressed on human neutrophils and at low level on monocytes. Multiple ligands have been identified for this integrin including the inducible endothelial counter-receptor, vascular cell adhesion molecule-1 (VCAM-1), the extracellular matrix proteins tenascin C and osteopontin, some members of ADAMs family, coagulation factor XIII, and von Willebrand factor. It has been reported that binding of the α9 cytoplasmic domain to spermidine/spermine N(1)-acetyltransferase (SSAT) mediates α9β1 enhancement of cell migration, mediates adhesion to the extracellular matrix proteins, and is involved in G-CSF signaling. More recently, integrin α9β1 was found on hematopoietic stem and progenitor cells to mediate stem cells adhesion, proliferation, and differentiation.